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ͺ¤Ç¤Ï¡¤Âоȷ²¤ËÈæ³Ó¤·¤Æ 100¤ª¤è¤Ó300 mg/kg·²¤ÇÇò·ìµå¿ô¤ÎÄãÃͤ¬Ç§¤á¤é¤ì¤¿¤¬¡¤Âоȷ²¤¬¹âÃÍ·¹¸þ¤Ë¤¢¤ê¡¤¤³¤ì¤é¤Î·²¤ÎÃͤËÌäÂê¤Ï¤Ê¤«¤Ã¤¿(ÇØ·ÊÃÍ¡¡11.8¡Þ3.5¡ß10^3/mm^3¡¤n=80)¡¥

»ó¤Ç¤Ï¡¤Âоȷ²¤ËÈæ³Ó¤·¤Æ 100 mg/kg·²¤ÇÇò·ìµå¿ô¤Î¹âÃÍ¡¤300 mg/kg·²¤ÇÄãÃͤ¬Ç§¤á¤é¤ì¤¿¤¬ÍÑÎÌÁê´ØÀ­¤Î¤Ê¤¤ÊѲ½¤Ç¤¢¤Ã¤¿¡¥

¡Ì²óÉü´ü´Ö½ªÎ»»þ¤Î¸¡ºº·ë²Ì¡Í

»óͺ¤È¤â¸¡ºº¤·¤¿¤¹¤Ù¤Æ¤Î¹àÌܤˤĤ¤¤Æ¡¤Âоȷ²¤È 1000 mg/kg·²¤È¤Çº¹¤¬Ç§¤á¤é¤ì¤Ê¤«¤Ã¤¿¡¥

6.¡¡·ì±Õ¶Å¸Ç¸¡ºº(Table 1)

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ͺ¤Ç¤Ï¡¤Âоȷ²¤ËÈæ³Ó¤·¤Æ 300¤ª¤è¤Ó1000 mg/kg·²¤Ç¥×¥í¥È¥í¥ó¥Ó¥ó»þ´Ö(PT)¤ª¤è¤Ó³èÀ­²½Éôʬ¥È¥í¥ó¥Ü¥×¥é¥¹¥Á¥ó»þ´Ö(APTT)¤¬±äŤò¼¨¤·¡¤¤µ¤é¤Ë1000 mg/kg·²¤Ç¥Õ¥£¥Ö¥ê¥Î¡¼¥²¥óÎ̤¬¹âÃͤò¼¨¤·¤¿¡¥PT¤ª¤è¤ÓAPTT¤Ë´Ø¤·¤Æ¤Ï¡¤Åý·×³ØŪͭ°Õº¹¤Ïǧ¤á¤é¤ì¤Ê¤«¤Ã¤¿¤â¤Î¤Î¡¤ÄãÍÑÎ̤Î100 mg/kg·²¤Ç¤â±äĹ·¹¸þ¤Ë¤¢¤Ã¤¿¡¥»ó¤Ç¤Ï¡¤Âоȷ²¤ËÈæ³Ó¤·¤Æ300¤ª¤è¤Ó1000 mg/kg·²¤ÇAPTT¤¬±äŤò¼¨¤·¡¤300 mg/kg·²¤ÇPT¤¬±äŤò¼¨¤·¤¿¡¥

¡Ì²óÉü´ü´Ö½ªÎ»»þ¤Î¸¡ºº·ë²Ì¡Í

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7.¡¡·ì±ÕÀ¸²½³Ø¸¡ºº(Table 2)

¡ÌÅêÍ¿½ªÎ»»þ¤Î¸¡ºº·ë²Ì¡Í

ͺ¤Ç¤Ï¡¤Âоȷ²¤ËÈæ³Ó¤·¤Æ¤¹¤Ù¤Æ¤ÎÈ︳ʪ¼ÁÅêÍ¿·²¤Ç GOT¤¬ÄãÃͤò¼¨¤·¡¤¤µ¤é¤Ë1000 mg/kg·²¤ÇÁí¥³¥ì¥¹¥Æ¥í¡¼¥ë¤¬¹âÃÍ¡¤±öÁǤ¬ÄãÃͤò¼¨¤·¤¿¡¥

»ó¤Ç¤Ï¡¤Âоȷ²¤ËÈæ³Ó¤·¤Æ¤¹¤Ù¤Æ¤ÎÈ︳ʪ¼ÁÅêÍ¿·²¤Ç GOT¤ª¤è¤Ó±öÁǤ¬ÄãÃͤò¼¨¤·¡¤¤µ¤é¤Ë1000 mg/kg·²¤ÇÁí¥³¥ì¥¹¥Æ¥í¡¼¥ë¤ª¤è¤ÓÁíÃÁÇò¤¬¹âÃͤò¼¨¤·¤¿¡¥

¡Ì²óÉü´ü´Ö½ªÎ»»þ¤Î¸¡ºº·ë²Ì¡Í

ͺ¤Ç¤Ï¡¤Âоȷ²¤ËÈæ³Ó¤·¤Æ 1000 mg/kg·²¤ÇÇ¢ÁÇÃâÁǤª¤è¤ÓGOT¤¬ÄãÃͤò¼¨¤·¡¤»ó¤Ç¤Ï¡¤Âоȷ²¤ËÈæ³Ó¤·¤Æ1000 mg/kg·²¤Ç¥¢¥ë¥«¥êÀ­¥Û¥¹¥Õ¥¡¥¿¡¼¥¼¤¬ÄãÃÍ¡¤ÁíÃÁÇò¡¤¥¢¥ë¥Ö¥ß¥ó¤ª¤è¤Ó¥«¥ê¥¦¥à¤¬¹âÃͤò¼¨¤·¤¿¡¥

8.¡¡Ç¢ ¸¡ ºº(Table 3)

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Âоȷ²¤ËÈæ³Ó¤·¤Æ¡¤»óͺ¤Î 300¤ª¤è¤Ó1000 mg/kg·²¤ÇÇ¢¿§¤ÎÊѲ½¤¬Ç§¤á¤é¤ì¡¤²«³ì¿§Ç¢Æ°Êª¤ÎÁý²Ã¤¬Ç§¤á¤é¤ì¤¿¡¥

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9.¡¡´ï´±½ÅÎÌ(Table 4)

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ͺ¤Ç¤Ï¡¤Âоȷ²¤ËÈæ³Ó¤·¤Æ 300¤ª¤è¤Ó1000 mg/kg·²¤Ç¿Õ¡½ÅÎ̤¬¹âÃͤò¼¨¤·¡¤¤µ¤é¤Ë1000 mg/kg·²¤Ç´Î¡½ÅÎ̤¬¹âÃͤò¼¨¤·¤¿¡¥

»ó¤Ç¤Ï¡¤Âоȷ²¤ËÈæ³Ó¤·¤Æ 300¤ª¤è¤Ó1000 mg/kg·²¤Ç¶»Á£½ÅÎ̤¬ÄãÃͤò¼¨¤·¡¤¤µ¤é¤Ë1000 mg/kg·²¤ÇǾ½ÅÎ̤¬ÄãÃÍ¡¤´Î¡½ÅÎ̤¬¹âÃͤò¼¨¤·¤¿¡¥¤½¤Î¾¡¤100 mg/kg·²¤Ç¤âǾ½ÅÎ̤¬ÄãÃͤò¼¨¤·¤¿¤¬¡¤ÍÑÎÌÁê´ØÀ­¤Î¤Ê¤¤ÊѲ½¤Ç¤¢¤Ã¤¿¡¥

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»ó¤Ç¤Ï¡¤Âоȷ²¤ËÈæ³Ó¤·¤Æ 1000 mg/kg·²¤Ç¶»Á£½ÅÎ̤¬ÄãÃͤò¼¨¤·¤¿¡¥

10.¡¡´ï´±½ÅÎÌ¡¦ÂνÅÈæ(ÁêÂнÅÎÌ)(Table 4)

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ͺ¤Ç¤Ï¡¤Âоȷ²¤ËÈæ³Ó¤·¤Æ 300¤ª¤è¤Ó1000 mg/kg·²¤Ç¿Õ¡ÁêÂнÅÎ̤¬¹âÃͤò¼¨¤·¡¤¤µ¤é¤Ë1000 mg/kg·²¤Ç´Î¡ÁêÂнÅÎ̤¬¹âÃͤò¼¨¤·¤¿¡¥

»ó¤Ç¤Ï¡¤Âоȷ²¤ËÈæ³Ó¤·¤Æ 1000 mg/kg·²¤ÇǾ¤ª¤è¤Ó´Î¡ÁêÂнÅÎ̤¬¹âÃͤò¼¨¤·¤¿¡¥

¡Ì²óÉü´ü´Ö½ªÎ»»þ¤Î¸¡ºº·ë²Ì¡Í

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»ó¤Ç¤Ï¡¤Âоȷ²¤È 1000 mg/kg·²¤Çº¹¤¬Ç§¤á¤é¤ì¤Ê¤«¤Ã¤¿¡¥

11.¡¡ÉÂÍý³Ø¸¡ºº

a)¡¡Ë¶¸¡½ê¸«(Table 5)

ÅêÍ¿½ªÎ»»þ¤Ë¤ª¤¤¤Æ¡¤Âоȷ²¤ËÈæ³Ó¤·¤ÆÈ︳ʪ¼ÁÅêÍ¿·²¤Ç¿¤¯´Ñ»¡¤µ¤ì¤¿½ê¸«¤È¤·¤Æ¡¤¿Õ¡¤ÎÈîÂ礬ͺ¤Î 300¡¤1000 mg/kg·²¤Ç¤½¤ì¤¾¤ì1¤ª¤è¤Ó4Î㡤»ó¤Î1000 mg/kg·²¤Ç1Îã¤Ë¡¤¿Õ¡¤Îø¿§²½¤¬Íº¤Î300¡¤1000 mg/kg·²¤Ç¤½¤ì¤¾¤ì2¤ª¤è¤Ó4Îã¤Ë´Ñ»¡¤µ¤ì¤¿¡¥¤Þ¤¿´Î¡¤ÎÈîÂ礬»ó¤Î1000 mg/kg·²¤Ç1Îã¤Ë´Ñ»¡¤µ¤ì¤¿¡¥¤½¤Î¾´Ñ»¡¤µ¤ì¤¿½ê¸«¤Ï¡¤Âоȷ²¡¤È︳ʪ¼ÁÅêÍ¿·²¤ÇñȯÀ­¤ÎȯÀ¸¤Ç¤¢¤Ã¤¿¡¥

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1)P. Kasirzewski A. Weaderna-Brychat and B. Czerski Determination of dimethylobenzoic acid isomers in wreie by gas chromatography. Medycyna Pracy, 45(1), 37(1994).
2)P. I Mikulski and R. Wiglusz, The comparative metofolism of mesitylen;pseudocumene, and heminellitene in rats. Toxicol. Appl. Pharmocol., 31(1), 21(1995).
3)Information Profiels of Potential Occupational Hazard:Trimethyl-benzens, Govt Reports Announcements & Index (GRA & I), Issue 15, 1987.
4)G. Feuer et al. Alanine aminotransferose activity of not tissues following the administration of cefazolin. Toxical. Appl. Pharmacol., 41, 185(1977).
5)¾¾¸¶¾°»Ö¡¤¸ÍÆâÌÀ¡¤¥é¥Ã¥È·ìÃ椪¤è¤Ó´ÎÆâ¹ÚÁdzèÀ­¤ËµÚ¤Ü¤¹Cefamandole¤Î±Æ¶Á:GTP³èÀ­Äã²¼µ¡ºî¤Î²òÀÏ¡¥Chemothorapy, 27, 740 (1979).
6)P. Greaves, "Urinary Tract, Histpathology of Preclinical Toxicity Studies," ELSEVIER, The Netherlands, 1990, pp.497-583

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Authors:Hiroyuki Inoue(Study director),
Susumu Kakamu, Akinori Shoji, Nobuaki Watari,
Kazuo Kobayashi, Yuka Matuki
Biosafety Research Center, Foods, Drugs and Pesticides(An-pyo Center)
582-2 Shioshinden Aza Arahama, Fukude-cho, Iwata-gun, Shizuoka, 437-12, Japan
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Tel 0538-58-1266Fax 0538-58-1393

Correspondence
Authors:Hiroyuki Inoue(Study director),
Susumu Kakamu, Akinori Shoji, Nobuaki Watari,
Kazuo Kobayashi, Yuka Matuki
Biosafety Research Center, Foods, Drugs and Pesticides(An-pyo Center)
582-2 Shioshinden Aza Arahama, Fukude-cho, Iwata-gun, Shizuoka, 437-12, Japan
Tel 81-538-58-1266Fax 81-538-58-1393