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Twenty-eight-day Repeat Dose Oral
Toxicity Test of 3,5-Dimethylaniline in Rats

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6¡¥·ì±ÕÀ¸²½³Ø¸¡ºº(Table 3)

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²óÉü´ü´Ö½ªÎ»»þ¤Î¸¡ºº¤Ç¤Ï¡¤360 mg/kg·²¤Î»óͺ¤Ç¥«¥ê¥¦¥à¤Î¸º¾¯¤¬¤ß¤é¤ì¤¿¤¬¡¤Íº¤ÎÃͤÏÅêÍ¿´ü´Ö½ªÎ»»þ¤è¤ê·Ú¸º¤·¤Æ¤ª¤ê¡¤²óÉü·¹¸þ¤¬Ç§¤á¤é¤ì¤¿¡¥¤½¤Î¤Û¤«¡¤360 mg/kg·²¤Îͺ¤ÇGOT¡¤¥°¥ë¥³¡¼¥¹¤ª¤è¤Ó¥¯¥ì¥¢¥Á¥Ë¥ó¤Î¸º¾¯¤¬¤ß¤é¤ì¤¿¤¬¡¤¤¤¤º¤ì¤â·ÚÅÙ¤ÊÊѲ½¤ÇÆÇÀ­³ØŪ¤Ë°ÕµÁ¤Î¤Ê¤¤ÊѲ½¤Ç¤¢¤Ã¤¿¡¥

7¡¥Ë¶¸¡

ÅêÍ¿´ü´Ö½ªÎ»»þ¤Î¸¡ºº¤Ç¤Ï¡¤ç£Â¡¤ÎÈîÂ礪¤è¤Ó¿Õ¡¤Î¹õ³ì¿§²½¤¬360 mg/kg·²¤Î»óͺÁ´Îã¤Ëǧ¤á¤é¤ì¤¿¡¥¤½¤Î¤Û¤«¡¤´Î¡¤Î²«Çò¿§ÅÀ¤¬360 mg/kg·²¤Î»ó1Îã¤Ë¡¤Ç٤ΰÅÀÖ¿§Èä¬Âоȷ²¤Îͺ1Îã¤Ëǧ¤á¤é¤ì¤¿¡¥

²óÉü´ü´Ö½ªÎ»»þ¤Î¸¡ºº¤Ç¤Ï¡¤ç£Â¡¤ÎÈîÂ礬360 mg/kg·²¤Îͺ3Îã¤È»ó1Îã¤Ëǧ¤á¤é¤ì¤¿¡¥¤½¤Î¤Û¤«¡¤ÀºÁã¾åÂÎ(º¸Â¦)¤Î²«Çò¿§ÅÀ¤¬360 mg/kg·²¤Î1Îã¤Ëǧ¤á¤é¤ì¤¿¡¥

8¡¥´ï´±½ÅÎÌ(Table 4)

ÅêÍ¿´ü´Ö½ªÎ»»þ¤Î¸¡ºº¤Ç¤Ï¡¤60¤ª¤è¤Ó360 mg/kg·²¤Î»óͺ¤Çç£Â¡¤ÎÀäÂФª¤è¤ÓÁêÂнÅÎ̤ÎÁý²Ã¤Ê¤¤¤·Áý²Ã·¹¸þ¤¬Ç§¤á¤é¤ì¤¿¡¥¤µ¤é¤Ë¡¤360 mg/kg·²¤Ç¤Ï¡¤¹Ã¾õÁ£¡¤´Î¡¤ª¤è¤Ó¿Õ¡¤ÎÀäÂФª¤è¤ÓÁêÂнÅÎ̤ÎÁý²Ã¤Ê¤¤¤·Áý²Ã·¹¸þ¤¬»óͺ¤Ëǧ¤á¤é¤ì¡¤ÀºÁã¤Ç¤âÀäÂФª¤è¤ÓÁêÂнÅÎ̤ËÁý²Ã¤¬Ç§¤á¤é¤ì¤¿¡¥¤½¤Î¤Û¤«¡¤60 mg/kg·²¤Îͺ¤Ç¤ÏÇÙ¤ÎÁêÂнÅÎ̤θº¾¯¤¬Ç§¤á¤é¤ì¤¿¤¬¡¤ÅêÍ¿Î̤ÈÊѲ½¤ÎÄøÅ٤˰ìÄê¤Î·¹¸þ¤Ïǧ¤á¤é¤ì¤Ê¤«¤Ã¤¿¡¥¤Þ¤¿¡¤360 mg/kg·²¤Îͺ¤Ç¤ÏǾ¤ª¤è¤Ó¿´Â¡¤ÎÁêÂнÅÎ̤ÎÁý²Ã¤¬Ç§¤á¤é¤ì¤¿¤¬¡¤ÀäÂнÅÎ̤ËÊѲ½¤Ï¤Ê¤¤¤³¤È¤«¤éÂνŤ¬ÄãÃͤǤ¢¤Ã¤¿¤³¤È¤Ëµ¯°ø¤¹¤ëÊѲ½¤È¹Í¤¨¤é¤ì¤¿¡¥

²óÉü´ü´Ö½ªÎ»»þ¤Î¸¡ºº¤Ç¤Ï¡¤ÅêÍ¿´ü´Ö½ªÎ»»þ¤ÈƱÍͤË360 mg/kg·²¤Î»óͺ¤Çç£Â¡¤ÎÀäÂФª¤è¤ÓÁêÂнÅÎ̤ÎÁý²Ã¡¤Æ±·²¤Î»ó¤Ç´Î¡¤ÎÀäÂФª¤è¤ÓÁêÂнÅÎ̤ÎÁý²Ã¤¬Ç§¤á¤é¤ì¤¿¤¬¡¤¤¤¤º¤ì¤âÊѲ½¤ÎÄøÅÙ¤ÏÅêÍ¿´ü´Ö½ªÎ»»þ¤ÈÈæ¤Ù¤Æ·Ú¸º¤·¤Æ¤ª¤ê¡¤²óÉü·¹¸þ¤¬Ç§¤á¤é¤ì¤¿¡¥¤½¤Î¤Û¤«¡¤360 mg/kg·²¤Îͺ¤Ç¤ÏǾ¤ÎÀäÂнÅÎ̤θº¾¯¤¬Ç§¤á¤é¤ì¤¿¡¥

9¡¥ÉÂÍýÁÈ¿¥³Ø¸¡ºº(Table 5)

ÅêÍ¿´ü´Ö½ªÎ»»þ¤Î˶¸¡Îã¤Ë¤ª¤¤¤Æ¡¤´Î¡¤Ç¤Ï¾®ÍÕÃæ¿´À­¤Î´ÎºÙ˦ÈîÂ礬60 mg/kg·²¤Îͺ3Î㤪¤è¤Ó360 mg/kg·²¤Î»óͺÁ´Îã¤Ë¡¤ÎàƶÆâºÙ˦¤Î¥Ø¥â¥¸¥Ç¥ê¥óÄÀÃ夬60 mg/kg·²¤Îͺ5Îã¤È»óÁ´Î㤪¤è¤Ó360 mg/kg·²¤Î»óͺÁ´Îã¤Ëǧ¤á¤é¤ì¡¤¤³¤ì¤é¤ÎÊѲ½¤ÎÄøÅÙ¤Ï360 mg/kg·²¤Ç¶¯¤«¤Ã¤¿¡¥¤Þ¤¿¡¤¾®ÍÕÊÕ±ï¤Î´ÎºÙ˦¤Î¥Ø¥â¥¸¥Ç¥ê¥óÄÀÃ夬360 mg/kg·²¤Î»ó2Îã¤Ë¡¤ÀÖ²êµå·Ï¤ò¼çÂΤȤ¹¤ë¿ñ³°Â¤·ì¤¬360 mg/kg·²¤Î»óͺÁ´Îã¤Ëǧ¤á¤é¤ì¤¿¡¥ç£Â¡¤Ç¤Ï¡¤ÀÖ²êµå·Ï¤ò¼çÂΤȤ¹¤ë¿ñ³°Â¤·ì¤¬60 mg/kg·²¤ÎͺÁ´Îã¤È»ó4Î㤪¤è¤Ó360 mg/kg·²¤Î»óͺÁ´Îã¤Ë¡¤ÀÖ磿ñ¤Ç¥Ø¥â¥¸¥Ç¥ê¥óÄÀÃ夬60¤ª¤è¤Ó360 mg/kg·²¤Î»óͺÁ´Îã¤Ëǧ¤á¤é¤ì¡¤¤³¤ì¤é¤ÎÊѲ½¤ÎÄøÅÙ¤Ï360 mg/kg·²¤Ç¶¯¤«¤Ã¤¿¡¥¶»¹ü¤ª¤è¤ÓÂçÂܹü¤Î¹ü¿ñ¤Ç¤Ï¡¤60 mg/kg·²¤ÎͺÁ´Î㤪¤è¤Ó360 mg/kg·²¤Î»óͺÁ´Îã¤ÇÀÖ²êµå·Ï¤Î¤·ìж¿Ê¤¬Ç§¤á¤é¤ì¡¤ÊѲ½¤ÎÄøÅÙ¤Ï360 mg/kg·²¤Ç¶¯¤«¤Ã¤¿¡¥¿Õ¡¤Ç¤Ï¡¤¶á°ÌÇ¢ºÙ´É¾åÈé¤Î¥Ø¥â¥¸¥Ç¥ê¥óÄÀÃ夬360 mg/kg·²¤Î»óͺÁ´Îã¤Ë¡¤¶á°ÌÇ¢ºÙ´É¾åÈé¤Î¾Ë»ÒÅ©¤¬360 mg/kg·²¤ÎͺÁ´Îã¤Ë¡¤ÆýƬ´Ö¼Á¤Î²õ»à¤¬360 mg/kg·²¤Îͺ3Îã¤È»óÁ´Îã¤Ëǧ¤á¤é¤ì¤¿¡¥¹Ã¾õÁ£¤Ç¤Ï¡¤ßÉ˦¾åÈéºÙ˦¤ÎÈîÂ礬60 mg/kg·²¤Îͺ1Î㤪¤è¤Ó360 mg/kg·²¤Î»óͺÁ´Îã¤Ëǧ¤á¤é¤ì¤¿¡¥¤½¤Î¤Û¤«¡¤360 mg/kg·²¤Î»ó1Îã¤Ç¤ÏÆù´ãŪ¤Ë´Î¡¤Î²«Çò¿§ÅÀ¤¬¤ß¤é¤ì¤¿Éô°Ì¤Ç¹­ÈÏÀ­²õ»à¤¬Ç§¤á¤é¤ì¡¤Âоȷ²¤Îͺ1Îã¤Ç¤ÏÆù´ãŪ¤ËÇ٤ΰÅÀÖ¿§È䬤ߤé¤ì¤¿Éô°Ì¤Ç½Ð·ì¡¤¿å¼ð¡¤¹¥Ãæµå¤Î¿»½á¤ª¤è¤ÓË¢Ë÷ºÙ˦¤Î½¸äȤ¬Ç§¤á¤é¤ì¤¿¡¥¤³¤Î¤Û¤«¤Ë¸¡ºº¤ò¹Ô¤Ã¤¿Ç¾¡¤´ãµå¡¤ÂñÕÁ£¡¤¾åÈé¾®ÂΡ¤¿´Â¡¡¤¶»Á£¡¤Éû¿Õ¤ª¤è¤ÓÀºÁã¤Ç¤ÏÊѲ½¤Ïǧ¤á¤é¤ì¤Ê¤«¤Ã¤¿¡¥

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1)M. Kornreich and C.A. Montgomery, Jr., "Toxicology and carcinogenesis studies of 2,6-xylidine(2,6-dimethylaniline)in Charles River CD rats," National Toxicology Program, Technical Report Series No.287(1990).
2)°æ¾åÇîÇ·¡¤²½³Øʪ¼ÁÆÇÀ­»î¸³Êó¹ð¡¤3¡¤143(1996).
3)ÃÝÆ⹯¹À¡¤¡ÈÆÇÀ­»î¸³¹ÖºÂ18¡¤»º¶È²½³Øʪ¼Á¡¤´Ä¶­²½³Øʪ¼Á¡ÉÏÂÅÄ¡¡¹¶ÊÔ¡¤ÃϿͽñ´Û¡¤Åìµþ¡¤1991¡¤pp. 129-151.
4)J.R. Glaister, "Principles of toxicological pathology," Taylar & Francis, London and Philadelphia, 1986, pp.83-85.
5)C. Gopinath, D.E. Prentice and D.J. Lewis, "Atlas of experimental toxicological pathology," MTP Press Limited, Lancaster, 1987, pp.112-113.
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Correspondence
Authors:Kazumi Suetake(Study director)
Hidehiro Ogata¡¤Hiromi Furukawa¡¤
Kuninori Yuki¡¤Kenji Nagai¡¤
Kouichi Kamiya¡¤Tsutomu Ichiki¡¤
Emiko Kuwasaki
Safety Assessment Laboratory, Panapharm Laboratories Co., Ltd.
1285 Kurisaki-machi, Uto-shi, Kumamoto, 869-04, Japan
Tel +81-964-23-5111Fax +81-964-23-2282