p-tert-Butylphenol

ρ-tert-ブチルフェノール

[CAS No. 98-54-4]

4-tert-Butylphenol

4-tert-ブチルフェノール

Molecular formula: C₁₀H₁₄O　Molecular weight: 150.22

ABSTRACT

An in vivo micronucleus test of p-tert-butylphenol was conducted with bone marrow cells from male CD-1 (ICR) mice. p-tert-Butylphenol did not induce micronuclei in bone marrow cells nor suppress their proliferation at a dose of 50 mg/kg.

SUMMARIZED DATA OF THE STUDY

1. Non-bacterial in vivo test (micronucleus test)¹⁾

Purity	:	99.9 %
Test species/strain	:	Mouse/Crj:CD-1 (ICR)
Test method	:	Guidelines for Screening Mutagenicity Testing of Chemicals (Chemincal Substances Control Law of Japan) and OECD Test Guideline 474
Route	:	Intraperitoneal injection
Dosage	:	0 (vehicle), 12.5, 25, 50 mg/kg
Number of animals/group	:	Males, 5
Vehicle	:	0.5 % Methylcellulose
Administration period	:	Single
Sampling time	:	24 and 48 hours
Positive control	:	Cyclophosphamide
Tissue	:	Bone marrow cells
GLP	:	Yes

　Test results:

In the preliminary toxicity study, p-tert-butylphenol induced convulsion and death in mice at a dose of 200 mg/kg, and decrease in locomotor activity at 100 mg/kg. The toxicity was not substantially different between sexes of mice. This chemical did not induce micronucleus in bone marrow cells nor suppress their proliferation at up to 50 mg/kg (the maximum tolerated dose)..

1) The test was performed by the Hatano Research Institute, Food and Drug Safety Center, 729-5 Ochiai, Hadano-shi, Kanagawa, 257-8523, Japan. Tel +81-463-82-4751 Fax +81-463-82-9627