Potassium 7-hydroxy-1,3-naphthalenedisulfonate

7-ヒドロキシ-1,3-ナフタレンジスルホン酸カリウム

[CAS No. 842-18-2]

Molecular formula: C₁₀H₆K₂O₇S₂　Molecular weight: 380.48

ABSTRACT

Potassium 7-hydroxy-1,3-naphthalenedisulfonate was studied for oral toxicity in rats in a 28-day repeat dose toxicity test at doses of 0, 100, 300 and 1000 mg/kg/day.

Hematological examination revealed increase in hematocrit, hemoglobin and RBCs, and a decrease in reticulocytes in females given 1000 mg/kg. Blood chemical examination revealed a decrease in total cholesterol in females given 300 and 1000 mg/kg. Absolute and relative spleen weights were decreased in males given 1000 mg/kg.

The NOELs for repeat dose toxicity are considered to be 300 mg/kg/day for males, and 100 mg/kg/day for females.

SUMMARIZED DATA FROM THE STUDIES

1. Repeat Dose Oral Toxicity ¹⁾

Purity	:	89.2 %
Test species/strain	:	Rat/Crj:CD(SD)
Test method	:	Guideline for 28-Day Repeated Dose Toxicity Test in Mammalian Species (Chemical Substances Control Law of Japan)
Route	:	Oral(gavage)
Doses	:	0(vehicle), 100, 300, 1000 mg/kg Number of animals/group
Administration period	:	Males and females; 14, 7, 7 and 14/group for the 0, 100, 300 and 1000 mg/kg, respectively
Recovery period	:	Males and females; 7 and 7/group for the 0 and 1000 mg/kg cases, respectively
Vehicle	:	1 % Carboxymethylcellulose sodium solution
Administration period	:	Males and females, 28 days
Terminal kill	:	Days 29 and 43
GLP	:	Yes

　Test results:

Hematological examination revealed an increase in hematocrit, hemoglobin and RBCs, and a decrease in reticulocytes in females given 1000 mg/kg. Blood chemical examination revealed a decrease in total cholesterol in females given 300 and 1000 mg/kg. Absolute and relative spleen weights were decreased in males given 1000 mg/kg.