With regard to repeat dose toxicity, the test substance had no effect on clinical signs, body weight, food consumption, necropsy findings, organ weights and histopathological findings for the testis and epididymis.
The NOELs for repeat dose toxicity are considered to be over 1000 mg/kg/day for both sexes.
In terms of reproductive/developmental toxicity, the compound showed no effects on any relevant parameters.
The NOELs for reproductive and developmental toxicity are considered to be 1000 mg/kg/day for both parental animals and offspring.
|Test species/strain||:||Rat/Crj:CD (SD)|
|Test method||:||OECD Preliminary Reproduction Toxicity Screening Test|
|Doses||:||0 (vehicle), 40, 200, 1000 mg/kg/day|
|Number of animals||:||Male, 10; female, 10/group|
|Vehicle||:||0.5% Sodium Carboxymethyl Cellulose solution|
|Administration period||:||Males, 41 days|
Females, from 14 days before mating to Day 3 of lactation
|Terminal kill||:||Males, Day 42|
Females, Day 4 of lactation
The NOELs for the repeat dose toxicity are considered to be over 1000 mg/kg/day for both sexes.
The NOELs for reproductive and developmental toxicity are considered to be over 1000 mg/kg/day for both parental animals and offspring.
|1)||The tests were performed by the Mitsubishi Chemical Safety Institute Ltd., 14 Sunayama, Hasaki-machi, Kashima-gun, Ibaraki, 314-02, Japan. Tel +81-479-46-2871 Fax +81-479-46-2874|