国立医薬品食品衛生研究所 安全性生物試験研究センター 総合評価研究室


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学会・誌上発表


誌上発表 2009年〜2011年


2011年

Hirata-Koizumi, M., Fujii, S., Ono, A., Hirose, A., Imai, T., Ogawa, K., Ema, M., Nishikawa, A. (2011). Evaluation of the reproductive and developmental toxicity of aluminium ammonium sulfate in a two-generation study in rats. Food Chem Toxicol49(9): 1948-1959.

Hirata-Koizumi, M., Fujii, S., Ono, A., Hirose, A., Imai, T., Ogawa, K., Ema, M., Nishikawa, A. (2011). Two-generation reproductive toxicity study of aluminium sulfate in rats. Reprod Toxicol 31(2): 219-30.

Hirose, A., Takagi, A., Nishimura, T., Tsuda, H., Sakamoto, Y., Ogata, A., Nakae, D., Hino, O., Kanno, J. (2011). [Importance of researches on chronic effects by manufactured nanomaterials]. Yakugaku Zasshi 131(2): 195-201.

Kobayashi, K., Sakuratani, Y., Abe, T., Yamazaki, K., Nishikawa, S., Yamada, J., Hirose, A., Kamata, E., Hayashi, M. (2011). Influence of coefficient of variation in determining significant difference of quantitative values obtained from 28-day repeated-dose toxicity studies in rats. J Toxicol Sci 36(1): 63-71.

Matsumoto, M., Miyachi, S., Sugaya, Y., Hirose, A. (2011). OECD High Production Volume Chemicals Programme: Summary of 29th SIDS Initial Assessment Meeting. ChemoBio Integrated Management 6(2): 189-198.

Takahashi, M., Matsumoto, M., Miyachi, S., Kanno, J., Sugaya, Y., Hirata-Koizumi, M., Hirose, A., Kamata, E., Ema, M. (2011). Progress on OECD Chemicals Programme (16) −SIAM 27 in Ottawa 2008. ChemoBio Integrated Management 6(2): 180-188.

Takahashi, M., Matsumoto, M., Miyachi, S., Kanno, J., Sugaya, Y., Hirata-Koizumi, M., Ono, A., Kamata, E., Hirose, A. (2011). Progress on OECD Chemicals Programme (17) ― SIAM 28 in Paris 2009. ChemoBio Integrated Management 7(1): 47-54.

村田勝敬, 苅田香苗, 堀口兵剛, 岩田豊人, 広瀬明彦 (2011). ベンチマークドース法の臨床的基準をもつ健康影響指標への適用. 産業衛生学雑誌 53(3): 67.

2010年

Ema, M., Ise, R., Kato, H., Oneda, S., Hirose, A., Hirata-Koizumi, M., Singh, A. V., Knudsen, T. B., Ihara, T. (2010). Fetal malformations and early embryonic gene expression response in cynomolgus monkeys maternally exposed to thalidomide. Reprod Toxicol 29(1): 49-56.

Hasegawa, R., Hirata-Koizumi, M., Dourson, M. L., Parker, A., Sweeney, L. M., Nishikawa, A., Yoshida, M., Ono, A., Hirose, A. (2010). Proposal of new uncertainty factor application to derive tolerable daily intake. Regul Toxicol Pharmacol 58(2): 237-42.

Kiyoshi, W., Yuri, K., Takuya, D., Shuichi, H., Akihiko, H. (2010). Effects of preparation methods for multi-wall carbon nanotube (MWCNT) suspensions on MWCNT induced rat pulmonary toxicity. J Toxicol Sci 35(4): 437-446.

Kobayashi, K., Sakuratani, Y., Abe, T., Nishikawa, S., Yamada, J., Hirose, A., Kamata, E., Hayashi, M. (2010). Relation between statistics and treatment-related changes obtained from toxicity studies in rats: if detected a significant difference in low or middle dose for quantitative values, this change is considered as incidental change? J Toxicol Sci 35(1): 79-85.

Matsumoto, M., Fujii, S., Hirose, A., Ema, M. (2010). Prenatal developmental toxicity of gavage or feeding doses of 2-sec-butyl-4,6-dinitrophenol in rats. Reprod Toxicol 29(3): 292-7.

Matsumoto, M., Miyachi, S., Sugaya, Y., Hirose, A. (2010). OECD High Production Volume Chemicals Programme: Summary of 28th SIDS Initial Assessment Meeting. ChemoBio Integrated Management 5(2): 201-209.

Nishikawa, A., Inoue, T., Umemura, T., Inoue, K., Yoshida, M., Sekita, K., Ishii, Y., Ogawa, K., Hirose, A., Takagi, A., Tsutsumi, T., Ohno, Y., Shibutani, M., Takahashi, M., Sugita-Konishi, Y., Akiyama, H., Kanno, J. (2010). [Current Topics in Biological Safety Tests on Foods, Food Additives and Contaminants]. Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) 51(6): 415-443.

Ono, A. (2010). [Perspective of predictive toxicity assessment of in vivo repeated dose toxicity using structural activity relationship]. Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku 128: 44-9.

Sakamoto, Y., Dai, N., Hagiwara, Y., Satoh, K., Ohashi, N., Fukamachi, K., Tsuda, H., Hirose, A., Nishimura, T., Hino, O., Ogata, A. (2010). Serum level of expressed in renal carcinoma (ERC)/ mesothelin in rats with mesothelial proliferative lesions induced by multi-wall carbon nanotube (MWCNT). J Toxicol Sci 35(2): 265-70.

Takahashi, M., Matsumoto, M., Miyachi, S., Kanno, J., Sugaya, Y., Hirata-Koizumi, M., Hirose, A., Kamata, E., Ema, M. (2010). Progress on OECD Chemicals Programme (15) ‐SIAM 25 in Helsinki 2007 and SIAM 26 in Paris 2008. ChemoBio Integrated Management 5(2): 193-200.

Xu, J., Futakuchi, M., Iigo, M., Fukamachi, K., Alexander, D. B., Shimizu, H., Sakai, Y., Tamano, S., Furukawa, F., Uchino, T., Tokunaga, H., Nishimura, T., Hirose, A., Kanno, J., Tsuda, H. (2010). Involvement of macrophage inflammatory protein 1alpha (MIP1alpha) in promotion of rat lung and mammary carcinogenic activity of nanoscale titanium dioxide particles administered by intra-pulmonary spraying. Carcinogenesis 31(5): 927-35.

広瀬明彦 (2010). 化学物質の安全性評価. 臨床薬理 41(2): 63S-64S.

小林克己, 櫻谷祐企, 阿部武丸, 山崎和子, 西川智, 山田隼, 広瀬明彦, 鎌田栄一, 林真 (2010). 化審法のラットを用いた28日間反復投与毒性試験に使用された病理組織学所見の統計解析法に対する一考察. 畜産の研究 64(9): 911-914.

小林克己, 櫻谷祐企, 阿部武丸, 西川智, 山田隼, 広瀬明彦, 鎌田栄一, 林真 (2010). ラットを用いた短期反復投与毒性試験の低用量群に統計学的有意差が検出される割合. 月刊PHARM STAGE 9(10): 49-52.

小林克己, 櫻谷祐企, 阿部武丸, 西川智, 山田隼, 広瀬明彦, 鎌田栄一, 林真 (2010). 毒性試験から得られる定量値に対する有効数値の桁数の差違およびMann-WhitneyのU検定とwilcoxonの検定の有意差検出の違い. 月刊PHARM STAGE 10(3): 45-48.

2009年

Ema, M., Arima, A., Fukunishi, K., Matsumoto, M., Hirata-Koizumi, M., Hirose, A., Ihara, T. (2009). Developmental toxicity of dibutyltin dichloride given on three consecutive days during organogenesis in cynomolgus monkeys. Drug Chem Toxicol 32(2): 150-7.

Hirata-Koizumi, M., Matsuno, K., Kawabata, M., Yajima, K., Matsuyama, T., Hirose, A., Kamata, E., Ema, M. (2009). Gender-related difference in the toxicity of 2-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole in rats: relationship to the plasma concentration, in vitro hepatic metabolism, and effects on hepatic metabolizing enzyme activity. Drug Chem Toxicol 32(3): 204-14.

Hirata-Koizumi, M., Matsuyama, T., Imai, T., Hirose, A., Kamata, E., Ema, M. (2009). Disappearance of gender-related difference in the toxicity of benzotriazole ultraviolet absorber in juvenile rats. Congenit Anom (Kyoto) 49(4): 247-52.

Hirose, A., Nishimura, T., Kanno, J. (2009). [Research strategy for evaluation methods of the manufactured nanomaterials in NIHS and importance of the chronic health effects studies]. Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku 127: 15-25.

Kubota, R., Tahara, M., Shimizu, K., Sugimoto, N., Hirose, A., Nishimura, T. (2009). [Development of a liquid chromatography-tandem mass spectrometry method for the determination of fullerenes C60 and C70 in biological samples]. Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku 127: 65-8.

Makris, S. L., Solomon, H. M., Clark, R., Shiota, K., Barbellion, S., Buschmann, J., Makoto, E., Fujiwara, M., Grote, K., Hazelden, K. P., Hew, K. W., Horimoto, M., Ooshima, Y., Parkinson, M., David, W. L. (2009). Terminology of Developmental Abnormalities in Common Laboratory Mammals (Version 2). Congenit Anom (Kyoto) 49(3): 123-246.

Matsumoto, M., Miyachi, S., Sugaya, Y., Ema, M., Hirose, A. (2009). OECD High Production Volume Chemicals Programme: Summary of 26th SIDS Initial Assessment Meeting. ChemoBio Integrated Management 4(2): 237-245.

Matsumoto, M., Miyachi, S., Sugaya, Y., Hirose, A. (2009). OECD High Production Volume Chemicals Programme: Summary of 27th SIDS Initial Assessment Meeting. ChemoBio Integrated Management 5(1): 105-115.

Nakazawa, T., Kasahara, K., Ikezaki, S., Yamaguchi, Y., Edamoto, H., Nishimura, N., Yahata, M., Tamura, K., Kamata, E., Ema, M., Hasegawa, R. (2009). Renal Tubular Cyst Formation in Newborn Rats Treated with p-Cumylphenol. J Toxicol Pathol 22(2): 125-131.

Sakamoto, Y., Nakae, D., Fukumori, N., Tayama, K., Maekawa, A., Imai, K., Hirose, A., Nishimura, T., Ohashi, N., Ogata, A. (2009). Induction of mesothelioma by a single intrascrotal administration of multi-wall carbon nanotube in intact male Fischer 344 rats. J Toxicol Sci 34(1): 65-76.

Takahashi, M., Matsumoto, M., Miyachi, S., Kanno, J., Sugaya, Y., Hirose, A., Kamata, E., Ema, M. (2009). Progress on OECD Chemicals Programme (14)― SIAM 23 in Jeju 2006 and SIAM 24 in Paris 2007. ChemoBio Integrated Management 4(2): 225-236.

Takahashi, M., Sunaga, M., Hirata-Koizumi, M., Hirose, A., Kamata, E., Ema, M. (2009). Reproductive and developmental toxicity screening study of 2,4-dinitrophenol in rats. Environ Toxicol 24(1): 74-81.

Upham, B. L., Park, J. S., Babica, P., Sovadinova, I., Rummel, A. M., Trosko, J. E., Hirose, A., Hasegawa, R., Kanno, J., Sai, K. (2009). Structure-activity-dependent regulation of cell communication by perfluorinated fatty acids using in vivo and in vitro model systems. Environ Health Perspect 117(4): 545-51.

広瀬明彦 (2009). おもちゃ等に汎用されるフタル酸エステル類の使用規制の根拠となった有害性評価. Endocr Disrupter News Lett 12(2): 6.

広瀬明彦 (2009). 化学物質の健康影響に関する基準値等の設定方法と最近の国際動向. 保健物理 44(3): 294-303.

広瀬明彦 (2009). 器具・容器包装に用いられる合成樹脂の毒性評価の考え方. 日本包装学会誌 18(1): 3-10.

小林克己, 櫻谷祐企, 阿部武丸, 西川智, 山田隼, 広瀬明彦, 鎌田栄一, 林真 (2009). ラットを用いた短期反復投与毒性試験から得られた定量値の解析法-中用量群のみ有意差が認められず用量依存性がない場合. 月刊PHARM STAGE 9(3): 62-69.


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  最終更新日 2012/02/01