国立医薬品食品衛生研究所 安全性生物試験研究センター 総合評価研究室


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学会・誌上発表


誌上発表 2006年〜2008年


2008年

Ema, M., Fujii, S., Hirata-Koizumi, M., Matsumoto, M. (2008). Two-generation reproductive toxicity study of the flame retardant hexabromocyclododecane in rats. Reprod Toxicol 25(3): 335-51.

Ema, M., Fujii, S., Matsumoto, M., Hirata-Koizumi, M., Hirose, A., Kamata, E. (2008). Two-generation reproductive toxicity study of the rubber accelerator N,N-dicyclohexyl-2-benzothiazolesulfenamide in rats. Reprod Toxicol 25(1): 21-38.

Ema, M., Fukunishi, K., Hirose, A., Hirata-Koizumi, M., Matsumoto, M., Kamata, E. (2008). Repeated-dose and reproductive toxicity of the ultraviolet absorber 2-(3',5'-di- tert-butyl-2'-hydroxyphenyl)-5-chlorobenzotriazole in rats. Drug Chem Toxicol 31(3): 399-412.

Ema, M., Hara, H., Matsumoto, M., Hirata-Koizumi, M., Hirose, A., Kamata, E. (2008). Evaluation of developmental neurotoxicity of polysorbate 80 in rats. Reprod Toxicol 25(1): 89-99.

Harada, T., Kimura, E., Hirata-Koizumi, M., Hirose, A., Kamata, E., Ema, M. (2008). Reproductive and developmental toxicity screening study of 4-aminophenol in rats. Drug Chem Toxicol 31(4): 473-86.

Hirata-Koizumi, M., Matsuyama, T., Imai, T., Hirose, A., Kamata, E., Ema, M. (2008). Gender-related difference in the toxicity of ultraviolet absorber 2-(3',5'-di-tert-butyl-2'-hydroxyphenyl)-5-chlorobenzotriazole in rats. Drug Chem Toxicol 31(3): 383-98.

Hirata-Koizumi, M., Matsuyama, T., Imai, T., Hirose, A., Kamata, E., Ema, M. (2008). Gonadal influence on the toxicity of 2-(2'-hydroxy-3',5'-di-tert-butylphenyl) benzotriazole in rats. Drug Chem Toxicol 31(1): 115-26.

Hirata-Koizumi, M., Matsuyama, T., Imai, T., Hirose, A., Kamata, E., Ema, M. (2008). Lack of gender-related difference in the toxicity of 2-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole in preweaning rats. Drug Chem Toxicol 31(2): 275-87.

Hirata-Koizumi, M., Noda, A., Hirose, A., Kamata, E., Ema, M. (2008). Reproductive and developmental toxicity screening test of tetrahydrofurfuryl alcohol in rats. Reprod Toxicol 25(2): 231-8.

Hirata-Koizumi, M., Ogata, H., Imai, T., Hirose, A., Kamata, E., Ema, M. (2008). A 52-week repeated dose toxicity study of ultraviolet absorber 2-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole in rats. Drug Chem Toxicol 31(1): 81-96.

Hirose, A., Hirano, S. (2008). Health Effects of Nanoparticles and Nanomaterials (III). Jpn. J. Hyg. (Nippon Eiseigaku Zasshi) 63(4): 739-45.

Katsumi, K., Yuki, S., Takemaru, A., Sadasivan, P. K., Eiichi, K., Makoto, H. (2008). Evaluation of statistical tools used in short-term repeated dose administration toxicity studies with rodents. J Toxicol Sci 33(1): 97-104.

Matsumoto, M., Furuhashi, T., Poncipe, C., Ema, M. (2008). Combined repeated dose and reproductive/developmental toxicity screening test of the nitrophenolic herbicide dinoseb, 2-sec-butyl-4,6-dinitrophenol, in rats. Environ Toxicol 23(2): 169-83.

Matsumoto, M., Hirata-Koizumi, M., Ema, M. (2008). Potential adverse effects of phthalic acid esters on human health: a review of recent studies on reproduction. Regul Toxicol Pharmacol 50(1): 37-49.

Matsumoto, M., Hirose, A., Ema, M. (2008). Review of testicular toxicity of dinitrophenolic compounds, 2-sec-butyl-4,6-dinitrophenol, 4,6-dinitro-o-cresol and 2,4-dinitrophenol. Reprod Toxicol 26(3-4): 185-90.

Matsumoto, M., Poncipe, C., Ema, M. (2008). Review of developmental toxicity of nitrophenolic herbicide dinoseb, 2-sec-butyl-4,6-dinitrophenol. Reprod Toxicol 25(3): 327-34.

Matsumoto, M., Yamamoto, N., Miyachi, S., Sugaya, Y., Ema, M. (2008). OECD High Production Volume Chemicals Programme: Summary of 25th SIDS Initial Assessment Meeting. ChemoBio Integrated Management 4(1): 136-143.

Takagi, A., Hirose, A., Nishimura, T., Fukumori, N., Ogata, A., Ohashi, N., Kitajima, S., Kanno, J. (2008). Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube. J Toxicol Sci 33(1): 105-16.

Takagi, A., Kitajima, S., Kanno, J., Hirose, A., Nishimura, T., Fukumori, N., Ogata, A., Ohashi, N. (2008). Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube. J Toxicol Sci 33(1): 105-116.

鎌田栄一 (2008). 化学物質の安全性試験結果公表システムとしての既存化学物質毒性データベース. CICSJ Bull (Div Chem Inf Comput Sci Chem Soc Jpn) 25: 96-98.

小林克己, 櫻谷祐企, 阿部武丸, 西川智, 山田隼, 広瀬明彦, 鎌田栄一, 林真 (2008). 日本と外国のげっ歯類を用いた毒性試験に使用された統計解析法の相違. 月刊PHARM STAGE 8: 40-48.

津田洋幸, 徳永裕司, 広瀬明彦, 菅野純 (2008). ナノマテリアルの有害性評価(毒性評価). 薬学雑誌 128(12): 1727-1732 .

2007年

Ema, M., Fujii, S., Ikka, T., Matsumoto, M., Hirose, A., Kamata, E. (2007). Early pregnancy failure induced by dibutyltin dichloride in mice. Environ Toxicol 22(1): 44-52.

Ema, M., Fukui, Y., Aoyama, H., Fujiwara, M., Fuji, J., Inouye, M., Iwase, T., Kihara, T., Oi, A., Otani, H., Shinomiya, M., Sugioka, K., Yamano, T., Yamashita, K. H., Tanimura, T. (2007). Comments from the Developmental Neurotoxicology Committee of the Japanese Teratology Society on the OECD Guideline for the Testing of Chemicals, Proposal for a New Guideline 426, Developmental Neurotoxicity Study, Draft Document (October 2006 version), and on the Draft Document of the Retrospective Performance Assessment of the Draft Test Guideline 426 on Developmental Neurotoxicity. Congenit Anom (Kyoto) 47(2): 74-6.

Ema, M., Fukunishi, K., Matsumoto, M., Hirose, A., Kamata, E., Ihara, T. (2007). Developmental toxicity of dibutyltin dichloride in cynomolgus monkeys. Reprod Toxicol 23(1): 12-9.

Ema, M., Ito, Y., Matsumoto, M., Hirose, A., Kamata, E. (2007). Screening study for repeated dose and reproductive/developmental toxicity of rubber accelerator, N,N-dicyclohexyl-2-benzothiazolesulfenamide, in rats. Drug Chem Toxicol 30(3): 167-80.

Ema, M., Matsumoto, M., Hirata-Koizumi, M., Fujii, S., Yabe, K. (2007). Evaluation of reproductive and developmental toxicity of the rubber accelerator N,N-dicyclohexyl-2-benzothiazolesulfenamide in rats Congenit Anom (Kyoto) 47(4): 149-155.

Hasegawa, R., Hirata-Koizumi, M., Dourson, M., Parker, A., Hirose, A., Nakai, S., Kamata, E., Ema, M. (2007). Pediatric susceptibility to 18 industrial chemicals: a comparative analysis of newborn with young animals. Regul Toxicol Pharmacol 47(3): 296-307.

Hirata-Koizumi, M., Watari, N., Mukai, D., Imai, T., Hirose, A., Kamata, E., Ema, M. (2007). A 28-day repeated dose toxicity study of ultraviolet absorber 2-(2'-hydroxy-3',5'-di-tert-butylphenyl) benzotriazole in rats. Drug Chem Toxicol 30(4): 327-41.

Matsumoto, M., Kusakabe, T., Kawahara, K., Sugaya, Y., Ema, M. (2007). OECD High Production Volume Chemicals Programme: Summary of 22nd SIDS Initial Assessment Meeting. ChemoBio Integrated Management 2(2): 302-312.

Matsumoto, M., Oi, T., Miyachi, S., Sugaya, Y., Ema, M. (2007). OECD High Production Volume Chemicals Programme: Summary of 23rd SIDS Initial Assessment Meeting. ChemoBio Integrated Management 3(1): 56-65.

Matsumoto, M., Yamamoto, N., Miyachi, S., Sugaya, Y., Ema, M. (2007). OECD High Production Volume Chemicals Programme: Summary of 24th SIDS Initial Assessment Meeting. ChemoBio Integrated Management 3(2): 180-189.

Takahashi, M., Matsumoto, M., Kawahara, K., Kanno, J., Sugaya, Y., Hirose, A., Kamata, E., Ema, M. (2007). Progress on OECD Chemicals Programme (10) - SIAM18 in Paris and 21 in Paris 2004. ChemoBio Integrated Management 2(2): 286-301.

Takahashi, M., Matsumoto, M., Kawahara, K., Kanno, J., Sugaya, Y., Hirose, A., Kamata, E., Ema, M. (2007). Progress on OECD Chemicals Programme (12) SIAM 20 in Paris and 21 in Washington DC 2005. ChemoBio Integrated Management 3(1): 43-55.

Takahashi, M., Matsumoto, M., Kawahara, K., Kanno, S., Sugaya, Y., Hirose, A., Kamata, E., Ema, M. (2007). [Progress on OECD Chemicals Programme (13)--SIAM 22 in Paris, 2006]. Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku 125: 101-6.

広瀬明彦 (2007). 食品の容器包装・器具のリスク評価法に関する研究. ポリ衛協会報 28: 29-36.

江馬眞 (2007). 生殖発生毒性試験の役割. 産科と婦人科 別冊 74(3): 309-315 .

2006年

Ema, M. (2006). Introduction to the OECD high production volume (HPV) chemicals programme. ChemoBio Integrated Management 2(1): 83-103.

Ema, M., Fujii, S., Matsumoto, M., Hirose, A., Kamata, E. (2006). Prenatal developmental toxicity study of the basic rubber accelerator, 1,3-di-o-tolylguanidine, in rats. Reprod Toxicol 22(4): 672-8.

Ema, M., Fukunishi, K., Matsumoto, M., Hirose, A., Kamata, E. (2006). Evaluation of developmental toxicity of ultraviolet absorber 2-(3',5'-di-tert-butyl-2'-hydroxyphenyl)-5-chlorobenzotriazole in rats. Drug Chem Toxicol 29(2): 215-25.

Ema, M., Kimura, E., Matsumoto, M., Hirose, A., Kamata, E. (2006). Reproductive and developmental toxicity screening test of basic rubber accelerator, 1,3-di-o-tolylguanidine, in rats. Reprod Toxicol 22(1): 30-6.

Hamamura, M., Hirose, A., Kamata, E., Katoku, K., Kuwasaki, E., Oshikata, T., Nakahara, Y., Ema, M., Hasegawa, R. (2006). Semi-quantitative immunohistochemical analysis of male rat-specific alpha2u-globulin accumulation for chemical toxicity evaluation. J Toxicol Sci 31(1): 35-47.

Matsumoto, M., Kawahara, K., Sugaya, Y., Ema, M. (2006). OECD High Production Volume Chemicals Programme: Summary of 21st SIDS Initial Assessment Meeting. ChemoBio Integrated Management 2(1): 135-146.

Matsumoto, M., Takahashi, M., Hirata-Koizumi, M., Hirose, A., Kamata, E., Hasegawa, A., Ema, M. (2006). OECD High Production Volume Chemicals Programme: Summary of 1st to 18th SIDS Initial Assessment Meetings. ChemoBio Integrated Management 2(1): 104-135.

Takahashi, M., Hirata-Koizumi, M., Nishimura, N., Ito, Y., Sunaga, M., Fujii, S., Kamata, E., Hasegawa, R., Ema, M. (2006). Susceptibility of newborn rats to 3-ethylphenol and 4-ethylphenol compared with that of young rats. Congenit Anom (Kyoto) 46(1): 26-33.

Takahashi, M., Matsumoto, M., Kawahara, K., Kanno, J., Sugaya, Y., Hirose, A., Kamata, E., Ema, M. (2006). Progress on OECD chemicals programme (8)− SIAM 16 in Paris, 2002− ChemoBio Integrated Management 2(1): 147-162.

Takahashi, M., Matsumoto, M., Kawahara, K., Kanno, J., Sugaya, Y., Hirose, A., Kamata, E., Ema, M. (2006). Progress on OECD Chemicals Programme (9) - SIAM 17 in Arona 2003. ChemoBio Integrated Management 2(1): 163-175.

Takahashi, M., Matsumoto, M., Kawahara, K., Kanno, S., Sugaya, Y., Hirose, A., Kamata, E., Ema, M. (2006). [Progress on OECD chemicals programme (11)--SIAM 19 in Berlin, 2004]. Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku 124: 62-8 .


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  最終更新日 2012/02/01