2-Naphthol

2-ナフトール

[CAS No. 135-19-3]

2-Hydroxynaphthalene

2-ヒドロキシナフタレン

Molecular formula: C10H8O        Molecular weight: 144.17

ABSTRACT

An in vivo micronucleus test of 2-naphthol was performed with bone marrow cells of male BDF1 mice. 2-Naphthol did not induce micronuclei in the bone marrow cells.

SUMMARIZED DATA FROM THE STUDY

1. Non-bacterial in vivo test(micronucleus test) 1)

Purity : 99.5 %
Test species/strain : Mouse/BDF1 (C57BL/6 × DBA/2)[SPF]
Test method : Guidelines for Screening Mutagenicity Testing of Chemicals (Chemical Substances Control Law of Japan) and OECD Test Guideline 474
 Route : Oral
 Dosage : 0, 62.5, 125, 250 mg/kg
 Number of animals/group : Males, 5
 Vehicle : 0.5 % Methylcellulose solution
 Administration period : Two days
 Sampling time : 24 hours after the second dose
 Positive control : Mitomycin C
 Tissue : Bone marrow cells
GLP : Yes

 Test results:

Toxic symptoms were observed at 250 mg/kg and above in the dose-finding study. There were no substantial differences between sexes in toxicity. This chemical did not induce micronucleated erythrocytes in mouse bone marrow cells at up to 250 mg/kg.
1) The test was performed by the Biosafety Research Center, Foods, Drugs and Pesticides (An-pyo Center), 582-2 Shioshinden, Iwata-shi, Shizuoka, 437-1213, Japan. Tel +81-538-58-1266, Fax +81-538-58-1393