While no adverse effects of 1,1'-azobisformamide were found in males, treatment with 1000 mg/kg to females caused death during the lactation period due to pelvic pyelonephritic kidney lesions.
Under the present conditions, NOELs for reproductive toxicity of 1,1'-azobisformamide are considered to be 1000 mg/kg/day for males and females, and those for toxicity other than reproduction are considered to be 1000 mg/kg/day for males and 300 mg/kg/day for females.
|Test method||:||OECD Test Guideline 415|
|Doses||:||0, 100, 300 and 1000 mg/kg|
|Number of animals/group||:||Males, 25; females, 25|
|Administration period||:||Males, 98 days|
Females, from 14 days before mating to day 20 of lactation
|Terminal kill||:||Males, day 99|
Females, day 21 of lactation
Offspring, 21 days after birth
No adverse effects on reproductive parameters of parent animals including viability, growth and morphology of offspring were observed.
The NOELs for reproduction are considered to be 1000 mg/kg/day for males and females including offspring. Those for toxicity other than reproduction are considered to be 1000 mg/kg/day for males and 300 mg/kg/day for females.
|1)||The test was performed by the Hatano Research Institute, Food and Drug Safety Center, 729-5 Ochiai, Hadano-shi, Kanagawa, 257-0025, Japan. Tel +81-463-82-4751 Fax +81-463-82-9627|